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Kupffer cells, the tissue resident macrophages of the liver, are activated through toll-like receptors by damage associated molecular patterns (DAMPs) released from necrotic hepatocytes

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Special attention is paid to the neuropsychiatric needs of movement disorders patients as well

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Liver metabolism during glucouronidation or sulfation, CYP activity and maintenance of hepatic GSH supply depends on patient factors such as age, nutritional status, pre-existing liver disease, concurrent use of alcohol and other liver-metabolized medications, genetic predispositions, and most importantly, the acuity or chronicity of APAP overuse.3,15,17,2030 Table 1